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(Fig 5-2) All DNA polymerases are single-minded they can do it only one way Each dNTP (deoxynucleoside triphosphate) is added to the 3 -OH group of the growing chain so that all chains grow from the 5 end in the dirction 5 to 3 Since strands are antiparallel, the template strand is read in the 3 to 5 direction This is true of both DNA and RNA synthesis Most of what you need to know about DNA replication can be summarized in a single picture To remember the order in which things happen, you must understand the structure of chromosomal DNA, and directions Then it s just a matter of developing a mechanical picture of how things must be done in order to get access to the information and make a copy Chromosomal DNA is normally packaged around histones At unique DNA sites called origins of replication, unwinding proteins (helicases) unwind the helix in an ATP-dependant manner Single-strand binding proteins then bind to and stabilize the single-stranded and DNA regions to keep them singlestranded In addition to a template (a DNA sequence that specifies the order in which the nucleotides will be jointed), DNA polymerase requires a primer A primer is a short piece of DNA or RNA that is complemen-

2 where w1 is Gaussian white noise with PSD 1 = 10 (m/s) , and = 1 rad Hz 2 s = v where is the di erence between The rate of change of d(t) is d the aircraft and runway heading Because the heading of the runway is constant and known, can be estimated from the yaw rate gyro as

Profit/loss by change in HD common price $ 840 700 560 420 280 140 0 140 280 1200 1400 1600 T+61 1800 2000 T+31 2200 2400 T+0 2600 2800 3000

FIGURE 7-3

(t) = r(t)

(734)

7:

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where r(t) = r(t) + w2 (t) and r represents the yaw rate, w2 is Gaussian 2 2 white noise with PSD 2 = 9 10 8 (rad/s) Hz De ne x = [d, , ] and = [w1 , w2 ] 1 De ne the kinematic equations for the state vector 2 De ne the state model for the system with the output d 3 Show that the state space model for the error state vector is 0 0 0 v 0 x = 0 0 x + 2 1 0 0 0 0 0 1 dk = 1 1 0 xk + nk 1 0 0 2 2 and that the PSD matrix for is Q =

4 Analyze the observability of the system 5 Predict the estimation accuracy for both d and d 6 The system model is time invariant Find the steady state Kalman gain K from the previous step Analyze the performance and com putational savings that could be achieved by using the K instead of Kk in the lter implementation Exercise 75 This problem returns to the application considered in Section 111 Exercise 56 derived the parameters of the Kalman lter design Accelerometer and position aiding measurements are posted on the website for the book 1 Implement the equations to integrate the (corrected) accelerometer measurements to produce an estimate of the navigation state vector 2 Implement the Kalman lter error estimator and use the estimated error state to correct the navigation state vector 3 Check the system design by analyzing the behavior of the residual aiding measurements relative to their expected behavior

the hybrid model by introducing the ability to embed Oracle OLAP multidimensional cubes in the relational database The Oracle Exadata Database Machine is often considered when organizations evaluate a platform to serve as an enterprise data warehouse (typically where a platform such as Teradata might also be under consideration) or where the platform serves as a high-performance data mart (typically where platforms such as those provided by IBM / Netezza or Microsoft might also be under consideration) Given the sophistication of the platform, many Oracle data warehousing implementations on the Oracle Exadata Database Machine contain consolidated data marts and warehouses Consolidation can take several forms, including the hosting of multiple data warehouses and data marts in separate databases or merging data marts and the enterprise data warehouse into a single hybrid data warehouse database Figure 7-4 serves to illustrate such possibilities, where the Oracle Exadata Database Machine is represented by the gray shading in the figure In addition

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